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111 Results

Exploring placental ultrastructure: A review of electron microscopy techniques and emerging methods for resolving 3D organelle architecture


The stroke risk gene Foxf2 maintains brain endothelial cell function via Tie2 signaling


Morphometric analysis of axonal ultrastructure: Coordinated scaling of organelles and myelin


Deep learning for brain electron microscopy segmentation: Advances, challenges, and future directions in connectomics and ultrastructure analysis


Characterization of astrocytic primary cilia in the adult mouse cortex and hippocampus


Hierarchical imaging: a new concept for targeted imaging of large volumes from cells to tissues


VTA monosynaptic connections by local glutamate and GABA neurons and their distinct roles in behavior


The synaptic architecture of layer 5 thick tufted excitatory neurons in mouse visual cortex


Scientists Map Miles of Wiring in a Speck of Mouse Brain – The New York Times


Functional connectomics spanning multiple areas of mouse visual cortex


Inhibitory specificity from a connectomic census of mouse visual cortex


Quantifying axonal features of human superficial white matter from three-dimensional multibeam serial electron microscopy data assisted by deep learning


MitoSeg: Mitochondria segmentation tool


Efficient cell-wide mapping of mitochondria in electron microscopic volumes using webKnossos


Comparative prospects of imaging methods for whole-brain mammalian connectomics


Volume electron microscopy reveals 3D synaptic nanoarchitecture in postmortem human prefrontal cortex


Volume electron microscopy reveals 3D synaptic nanoarchitecture in postmortem human prefrontal cortex


Whole-brain annotation and multi-connectome cell typing of Drosophila


Evolution of the ribbon-like organization of the Golgi apparatus in animal cells


Apolipoprotein E aggregation in microglia initiates Alzheimer’s disease pathology by seeding b-amyloidosis


Scalability and stability in CO2 reduction via tomography-guided system design


Mitochondria-ER contact sites expand during mitosis


Volume electron microscopy for genetically and molecularly defined neural circuits


GAUSS-EM, guided accumulation of ultrathin serial sections with a static magnetic field for volume electron microscopy


Mitochondria ER Contact sites expand during mitosis


GAUES-EM, Guided accumulation of ultrathin serial sections with a static magnetic field for volume electron microscopy


Remyelination by surviving oligodendrocytes is inefficient in the inflamed mammalian cortex


Multiplexed volumetric CLEM enabled by scFvs provides insights into the cytology of cerebellar cortex


RoboEM: automated 3D flight tracing for synaptic-resolution connectomics


Friction forces determine cytoplasmic reorganization and shape changes of ascidian oocytes upon fertilization


Nonvesicular lipid transfer drives myelin growth in the central nervous system


Fast imaging of millimeter-scale areas with beam deflection transmission electron microscopy


vEM reveals the cellular composition of the Blood Nerve Barrier​


ATUM-Tomo: A multi-scale approach to cellular ultrastructure by combined volume scanning electron microscopy and electron tomography


Distinct molecular profiles of skull bone marrow in health and neurological disorders


Remyelination by surviving oligodendrocytes is inefficient in the inflamed mammalian cortex


High-contrast en bloc staining of mouse whole-brain and human brain samples for EM-based connectomics


Developmental exposure to domoic acid targets reticulospinal neurons and leads to aberrant myelination in the spinal cord


Spatial Transcriptomics-correlated Electron Microscopy maps transcriptional and ultrastructural responses to brain injury


Insights into the leaky Blood Brain Barrier by vEM


Finding Needles in a Haystack with Light: Resolving the Microcircuitry of the Brain with Fluorescence Microscopy


3D multiscale analysis of the hierarchical porosity in Coscinodiscus sp. diatoms using a combination of tomographic techniques


Reconstructing neural circuits using multiresolution correlated light and electron microscopy


Multi-scale light microscopy/electron microscopy neuronal imaging from brain to synapse with a tissue clearing method, ScaleSF


Deep residual contextual and subpixel convolution network for automated neuronal structure segmentation in micro-connectomics


Research Techniques Made Simple: Volume Scanning Electron Microscopy


Fear memory-associated synaptic and mitochondrial changes revealed by deep learning-based processing of electron microscopy data


Local shape descriptors for neuron segmentation


CD8+ T cells induce interferon-responsive oligodendrocytes and microglia in white matter aging


How volumeEM (vEM) can help map neuronal circuits


Niwaki Instead of Random Forests: Targeted Serial Sectioning Scanning Electron Microscopy With Reimaging Capabilities for Exploring Central Nervous System Cell Biology and Pathology


Cryo-Confocal Imaging for CLEM Mapping in Brain Tissues


A connectomic study of a petascale fragment of human cerebral cortex


Connectomes across development reveal principles of brain maturation


Rapid Ultrastructural Changes in the PSD and Surrounding Membrane after Induction of Structural LTP in Single Dendritic Spines


Reconstruction of motor control circuits in adult Drosophila using automated transmission electron microscopy


Microscopy techniques for protocell characterization


Large-scale 3D imaging of mouse cochlea using serial block-face scanning electron microscopy


Primate neuronal connections are sparse in cortex as compared to mouse


White matter aging drives microglial diversity


Protocol for preparation of heterogeneous biological samples for 3D electron microscopy: a case study for insects


An App knock-in rat model for Alzheimer’s disease exhibiting Aβ and tau pathologies, neuronal death and cognitive impairments


Multi-modal imaging of a single mouse brain over five orders of magnitude of resolution


Emerging electron microscopy and 3D methodologies to interrogate Staphylococcus aureus osteomyelitis in murine models


ATUM-FIB microscopy for targeting and multiscale imaging of rare events in mouse cortex


Analysis of the three dimensional structure of the kidney glomerulus capillary network


Myelin replacement triggered by single-cell demyelination in mouse cortex


Mitochondrial Protrusions in Neuronal Cells


Transmission imaging on a scintillator in a scanning electron microscope


Correlative Ultrastructural Analysis of Functionally Modulated Synapses Using Automated Tape-Collecting Ultramicrotome and SEM Array Tomography Correlative Ultrastructural Analysis of Functionally Modulated Synapses Using Automated Tape-Collecting Ultramicrotome and SEM Array Tomography


Multiscale Imaging with Photons, Electrons and Ions


Multiscale ATUM-FIB Microscopy Enables Targeted Ultrastructural Analysis at Isotropic Resolution


Long-Range Optogenetic Control of Axon GuidanceOvercomes Developmental Boundaries and Defects


Intercellular Communication in the Mouse Ovarian Follicle Analyzed by Three-Dimensional Electron Microscopy


A petascale automated imaging pipeline for mapping neuronal circuits with high-throughput transmission electron microscopy


Myelin replacement triggered by single-cell demyelination in mouse cortex


An Individual Interneuron Participates in Many Kinds of Inhibition and Innervates Much of the Mouse Visual Thalamus


Serial section Raman tomography with 10 times higher depth resolution than confocal Raman microscopy


Neuronal BIN1 Regulates Presynaptic Neurotransmitter Release and Memory Consolidation


Sensory Experience Engages Microglia to Shape Neural Connectivity through a Non-Phagocytic Mechanism


Developmental Rewiring between Cerebellar Climbing Fibers and Purkinje Cells Begins with Positive Feedback Synapse Addition


Serial-section electron microscopy using automated tape-collecting ultramicrotome (ATUM)


Presynaptic Mitochondria Volume and Abundance Increase during Development of a High-Fidelity Synapse


Microscopy Techniques for NEUROSCIENCE


UNI-EM: An Environment for Deep Neural Network-Based Automated Segmentation of Neuronal Electron Microscopic Images


Three-dimensional organization of transzonal projections and other cytoplasmic extensions in the mouse ovarian follicle


Brain activity regulates loose coupling between mitochondrial and cytosolic Ca2+ transients


Lateral Inhibition in Cell Specification Mediated by Mechanical Signals Modulating TAZ Activity


A Complete Electron Microscopy Volume of the Brain of Adult Drosophila melanogaster


Large Volume Electron Microscopy and Neural Microcircuit Analysis


Correlated Light-Serial Scanning Electron Microscopy (CoLSSEM) for ultrastructural visualization of single neurons in vivo


Flexible Learning-Free Segmentation and Reconstruction of Neural Volumes


A micro-CT-based method for quantitative brain lesion characterization and electrode localization


Informative three-dimensional survey of cell/tissue architectures in thick paraffin sections by simple low-vacuum scanning electron microscopy


Progress and remaining challenges in high-throughput volume electron microscopy


A carbon nanotube tape for serial-section electron microscopy of brain ultrastructure


Whole-brain serial-section electron microscopy in larval zebrafish


Localization of phosphorylated connexin 43 using serial section immunogold electron microscopy


Electron Microscopic Reconstruction of Functionally Identified Cells in a Neural Integrator


A novel imaging method for correlating 2D light microscopic data and 3D volume data based on block-face imaging